Tramadol+Paracetamol ( 37.5mg/325mg Tablet)
Analgesics (Opioid) / Supportive Care Therapy
|Mode of Action||
Description: Tramadol is a centrally acting opioid analgesic which binds to mu-opioid receptors and weakly inhibits the reuptake of norepinephrine and serotonin. Paracetamol, a para-aminophenol derivative, has analgesic, antipyretic and weak anti-inflammatory activity. Together, tramadol and paracetamol has faster onset of action compared to tramadol alone and longer duration of action compared to paracetamol alone.
For management of moderate to severe pain.
|Dosage / Direction of Use||
Adult & childn >16 yr 1-2 tab 4-6 hrly. Max: 8 tab/day.
Acute intoxication w/ alcohol, hypnotics, narcotics, centrally-acting analgesic, opioids or psychotropic.
Contains tartrazine that may cause allergic reactions.
Increased risk of seizures and serotonin syndrome w/ SSRIs, SNRIs, TCAs, and 5-HT agonists (e.g. sumatriptan). Increased CNS depression w/ barbiturates, benzodiazepines, other anxiolytics, hypnotics, sedative antidepressants, sedative antihistamines, neuroleptics, centrally-acting antihypertensive drugs, thalidomide and baclofen. Decreased analgesic efficacy w/ ondansetron. Increased INR w/ warfarin.
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