Cetra Tablet


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Generic Name

Tramadol+Paracetamol ( 37.5mg/325mg Tablet)



Therapeutic Class

Analgesics (Opioid)  / Supportive Care Therapy

Mode of Action

Description: Tramadol is a centrally acting opioid analgesic which binds to mu-opioid receptors and weakly inhibits the reuptake of norepinephrine and serotonin. Paracetamol, a para-aminophenol derivative, has analgesic, antipyretic and weak anti-inflammatory activity. Together, tramadol and paracetamol has faster onset of action compared to tramadol alone and longer duration of action compared to paracetamol alone.
Duration: 5 hr.
Absorption: Readily absorbed from GI tract. Tramadol: Bioavailability: Approx 70-75% (oral); 100% (IM). Paracetamol: Time to peak plasma concentration: 10-60 min.
Distribution: Widely distributed, crosses the placenta and distributesd into the breast milk. Plasma protein binding: Approx 20% (tramadol); negligible (paracetamol).
Metabolism: Tramadol: Undergoes N- and O-demethylation by CYP3A4 and CYP2D6 isoenzymes and also by glucuronidation and sulfation. Paracetamol: Hepatic via glucuronic and sulfuric acid conjugation.
Excretion: Tramadol: Via urine as metabolites. Elimination half-life: Approx 6 hr. Paracetamol: Via urine as glucuronide and sulfate conjugates; <5% as unchanged drug Elimination half life: Approx 1-3 hr.


For management of moderate to severe pain.

Dosage / Direction of Use

Adult & childn >16 yr 1-2 tab 4-6 hrly. Max: 8 tab/day.


Acute intoxication w/ alcohol, hypnotics, narcotics, centrally-acting analgesic, opioids or psychotropic.

Special Precaution

Contains tartrazine that may cause allergic reactions.

Drug Interaction

Increased risk of seizures and serotonin syndrome w/ SSRIs, SNRIs, TCAs, and 5-HT agonists (e.g. sumatriptan). Increased CNS depression w/ barbiturates, benzodiazepines, other anxiolytics, hypnotics, sedative antidepressants, sedative antihistamines, neuroleptics, centrally-acting antihypertensive drugs, thalidomide and baclofen. Decreased analgesic efficacy w/ ondansetron. Increased INR w/ warfarin.
Potentially Fatal: May enhance serotonergic, neuroexcitatory and/or seizure-potentiating effect of MAOIs.


Php 2,909.09

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