Co-Amoxiclav 500mg/125mg Film-coated Tablet
|Mode of Action||
Amoxicillin is a semisynthetic antibiotic with a broad-spectrum of bactericidal activity against many gram-positive and -negative microorganisms. Amoxicillin is, however, susceptible to degradation by β-lactamases and therefore, the spectrum of activity does not include organisms, which produce these enzymes. Clavulanic acid is a β-lactam, structurally related to the penicillins, which possesses the ability to inactivate a wide range of β-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid mediated β-lactamases frequently responsible for transferred drug resistance. The formulation of amoxicillin and clavulanic acid protects amoxicillin from degradation by β-lactamase enzymes and effectively extends the antibiotic spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other β-lactam antibiotics. Thus, amoxicillin/clavulanate potassium combination possesses the distinctive properties of a broad-spectrum antibiotic and a β-lactamase inhibitor.
Infections due to β-lactamase-producing strains (where amoxicillin alone is not appropriate) including resp tract, GUT, abdominal & severe dental, skin & soft tissue infections; cellulitis, animal bites, acute otitis media, sinusitis & UTI.
|Dosage / Direction of Use||
Adult 625-mg to 1-g tab 12 hrly. Severe infections 625-mg to 1-g tab 8 hrly.
Patients with a history of allergic reactions to any penicillin. Attention should be paid to possible cross-sensitivity with other β-lactam antibiotics eg, cephalosporins. Patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with CO-AX.
Renal & hepatic impairment. Pregnancy & lactation. Elderly.
Probenecid, anticoagulants, OCs, allopurinol
CO-AX Tablet 500mg
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