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CO-AX Tablet 500mg

Antiinfective

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Generic Name

Co-Amoxiclav 500mg/125mg Film-coated Tablet

Availability

60's

Therapeutic Class

Anti-Infectives

Mode of Action

Amoxicillin is a semisynthetic antibiotic with a broad-spectrum of bactericidal activity against many gram-positive and -negative microorganisms. Amoxicillin is, however, susceptible to degradation by β-lactamases and therefore, the spectrum of activity does not include organisms, which produce these enzymes. Clavulanic acid is a β-lactam, structurally related to the penicillins, which possesses the ability to inactivate a wide range of β-lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid mediated β-lactamases frequently responsible for transferred drug resistance. The formulation of amoxicillin and clavulanic acid protects amoxicillin from degradation by β-lactamase enzymes and effectively extends the antibiotic spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other β-lactam antibiotics. Thus, amoxicillin/clavulanate potassium combination possesses the distinctive properties of a broad-spectrum antibiotic and a β-lactamase inhibitor.

Indication

Infections due to β-lactamase-producing strains (where amoxicillin alone is not appropriate) including resp tract, GUT, abdominal & severe dental, skin & soft tissue infections; cellulitis, animal bites, acute otitis media, sinusitis & UTI.

Dosage / Direction of Use

Adult 625-mg to 1-g tab 12 hrly. Severe infections 625-mg to 1-g tab 8 hrly.

Contraindication

Patients with a history of allergic reactions to any penicillin. Attention should be paid to possible cross-sensitivity with other β-lactam antibiotics eg, cephalosporins. Patients with a previous history of cholestatic jaundice/hepatic dysfunction associated with CO-AX.

Special Precaution

Renal & hepatic impairment. Pregnancy & lactation. Elderly.

Drug Interaction

Probenecid, anticoagulants, OCs, allopurinol

Price

Php 2,127.27

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