Meloxicam (15mg Tablet)
Non-steroidal antiinflammatory and antirheumatic
|Mode of Action||
Meloxicam has analgesic, anti-inflammatory, and antipyretic properties. The mechanism of action of Meloxicam, like that of other NSAIDs, is not completely understood but involves inhibition of cyclooxygenase (COX-1 and COX-2). Meloxicam is a potent inhibitor of prostaglandin synthesis in vitro. Meloxicam concentrations reached during therapy have produced in vivo effects. Prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain in animal models. Prostaglandins are mediators of inflammation. Because Meloxicam is an inhibitor of prostaglandin synthesis, its mode of action may be due to a decrease of prostaglandins in peripheral tissues.
Pain & inflammation in rheumatic disease; exacerbation of OA (short-term); ankylosing spondylitis.
|Dosage / Direction of Use||
RA, ankylosing spondylitis 15 mg/day as single dose. Elderly (long-term treatment) 7.5 mg/day. Acute OA exacerbations 7.5 mg, may be increased to a max of 15 mg/day as single dose. Patient undergoing dialysis 7.5 mg.
Hypersensitivity to aspirin or other NSAIDs. History of stroke, cerebrovascular accidents, MI, CABG, uncontrolled HTN, CHF NYHA IHV.
History & active peptic ulceration. Cardiac, liver & renal disease. Monitor renal & liver functions.
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