Levofloxacin ( 500mg Tablet)
|Mode of Action||
Levofloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Like all quinolones, it functions by inhibiting the DNA gyrase and topoisomerase IV (two bacterial type II topoisomerases), enzymes required for DNA replication, transcription, repair and recombination.
Treatment of susceptible infections eg, skin & soft tissue infections, UTI, exacerbation of chronic bronchitis, community-acquired pneumonia.
|Dosage / Direction of Use||
Susceptible infections 250 or 500 mg once daily or bid. Community-acquired pneumonia 500 mg for 7-14 days or 750 mg for 5 days. Nosocomial pneumonia 500 or 750 mg for 7-14 days. Acute bacterial exacerbation of chronic bronchitis 500 mg for 7 days. Acute bacterial sinusitis 500 mg for 10-14 days or 750 mg for 5 days. Complicated skin & skin structure infections 500 mg for 7-14 days. Uncomplicated skin & skin structure infections 500 mg for 7-10 days. Chronic bacterial prostatitis 500 mg for 28 days.Complicated UTI, acute pyelonephritis 250 mg for 10 days. Uncomplicated UTI 250 mg for 3 days. Patient w/ CrCl 20-49 mL/min Initially 750 mg followed by 750 mg 48 hrly;10-19 mL/min, patient undergoing hemodialysis & CAPD Initially 750 mg followed by 500 mg 48 hrly; patient w/ complicated skin & skin structure 750 mg 24 hrly 7-14 days.
Hypersensitivity to quinolones.
Epilepsy or a history of CNS disorders. Avoid MRSA infections. Impaired renal or hepatic function. G6PD deficiency, myasthenia gravis.
Decreased absorption with Fe salts, Zn-containing multivitamins, Mg- or Al-containing antacids, didanosine. Decreased bioavailability with sucralfate. Increased risk of CNS stimulation and seizures with drugs which may affect seizure threshold (e.g. theophylline, NSAIDs). Decreased renal clearance with cimetidine and probenecid due to blockage of renal tubular secretion of levofloxacin. May increase the half-life of ciclosporin. Increased INR and/or bleeding with vitamin K antagonists (e.g. warfarin). Increased risk of severe tendon disorders with corticosteroids. Increased risk for QT interval prolongation with class IA and III antiarrhythmics, TCA, macrolides and antipsychotic agents. May result to altered blood glucose levels with antidiabetic agents (e.g. insulin, glibenclamide).
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