Mode of Action
Antibacterial Pharmacology: Pharmacokinetics: Cefuroxime axetil is absorbed from the GIT and is rapidly hydrolyzed in the intestinal mucosa and blood to cefuroxime. Absorption is enhanced in the presence of food. Peak plasma concentrations are reported about 2-3 hrs after an oral dose. It is widely distributed in the body including pleural fluid, sputum, synovial fluid and aqueous humor, but only achieves therapeutic concentrations in the CSF when the meninges are inflamed. It crosses the placenta and has been detected in breast milk. It is excreted unchanged by glomerular filtration and renal tubular secretion and high concentrations are achieved in the urine.
Oral susp: Treatment of susceptible infections including bone & joint; bronchitis (& other lower resp tract infections), gonorrhea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections (including soft tissue infections) & UTI. Surgical infection prophylaxis.
Oral susp Adult Uncomplicated resp tract infection 2.5 mL bid. Resp tract infection 5-10 mL bid. Childn >2 yr Otitis media 5 mL or 15 mg/kg bid. Max: 10 mL daily. >3 mth 2.5 mL or 10 mg/kg bid. Max: 5 mL daily.
Hypersensitivity to Cephalosporin
History of allergy. Oral susp: Patients w/ renal impairment. Monitor renal hematological status especially during prolonged & high-dose therapy.
Reduced renal clearance w/ probenecid.